Summary The Hermansky–Pudlak syndrome (HPS) is a collection of related autosomal
recessive disorders which are genetically heterogeneous. There are eight human HPS …

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

Background Cigarette smoking is associated with emphysema and radiographic interstitial
lung abnormalities. The degree to which interstitial lung abnormalities are associated with …

Background Early detection and treatment for interstitial lung disease (ILD) in patients with
rheumatoid arthritis (RA) may ameliorate disease progression. The objective of this study …

Background: Platelets have three major types of secretory organelles: lysosomes, dense
granules, and α‐granules. α‐Granules contain several adhesive proteins involved in …

Current programmable nuclease-based methods (for example, CRISPR–Cas9) for the
precise correction of a disease-causing genetic mutation harness the homology-directed …

Hermansky–Pudlak syndrome (HPS) is a group of 10 autosomal recessive multisystem
disorders, each defined by the deficiency of a specific gene. HPS‐associated genes encode …

Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …

A set of lung diseases share the tendency for the development of progressive fibrosis
ultimately leading to respiratory failure. This review examines the common pathogenetic …

Hermansky–Pudlak syndrome (HPS) is a rare autosomal recessive genetic disorder
characterized by oculocutaneous albinism and a bleeding diathesis due to platelet …