Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

Surveillance of drug resistance and the discovery of novel targets—key objectives in the
fight against malaria—rely on identifying resistance-conferring mutations in Plasmodium …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

One of the most powerful approaches to understanding gene function involves turning
genes on and off at will and measuring the impact at the cellular or organismal level. This …

Mitochondrial respiration is a critical process for the survival of many eukaryotes, including
parasites in the phylum Apicomplexa. These intracellular parasites include the causative …

Apicomplexans are widespread parasites of humans and other animals, and include the
causative agents of malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii) …

In the glucose-rich milieu of red blood cells, asexually replicating malarial parasites mainly
rely on glycolysis for ATP production, with limited carbon flux through the mitochondrial …

The mitochondrion of malaria parasites contains several clinically validated drug targets.
Within Plasmodium spp., the causative agents of malaria, the mitochondrial DNA (mtDNA) is …

Nearly half of the world's population is at risk of being infected by Plasmodium falciparum,
the pathogen of malaria. Increasing resistance to common antimalarial drugs has …