Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent
adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes
after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and …

Cadmium (Cd) is a highly toxic environmental pollutant released from the smelting and
refining of metals and cigarette smoking. Oral exposure to cadmium may result in adverse …

Background Neuropathic pain is a clinically relevant adverse effect of several anticancer
drugs that markedly impairs patients' quality of life and frequently leads to dose reduction or …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells,
including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation …

Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite
its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment …

Evidence for striatal A2A‐D2 heterodimers has led to a new perspective on molecular
mechanisms involved in schizophrenia and Parkinson's disease. Despite the increasing …

Purinergic signalling in the brain is becoming an important focus in the study of CNS health
and disease. Various purinergic receptors are found to be present in different brain cells in …