tRNA dysregulation and disease

EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

The life and times of a tRNA

EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress

SP Hwang, H Liao, K Barondeau, X Han, C Herbert… - Cell Reports, 2025 - cell.com
Summary tRNA modifications are critical for several aspects of their functions, including
decoding, folding, and stability. Using a multifaceted approach encompassing eCLIP-seq …

[HTML][HTML] tsRNA modifications: an emerging layer of biological regulation in disease

Y Liang, D Ji, X Ying, R Ma, W Ji - Journal of Advanced Research, 2024 - Elsevier
Abstract Background Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an
important and increasingly valued type of small non-coding RNA (sncRNA). The …

Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

M Tasak, EM Phizicky - PLoS genetics, 2022 - journals.plos.org
All tRNAs have numerous modifications, lack of which often results in growth defects in the
budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In …

Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA …

A Garg, AM Sanchez, M Miele, B Schwer… - Nucleic acids …, 2023 - academic.oup.com
Inorganic phosphate is an essential nutrient acquired by cells from their environment. Here,
we characterize the adaptative responses of fission yeast to chronic phosphate starvation …

The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues

AM Añazco-Guenkova, B Miguel-López… - NAR …, 2024 - academic.oup.com
Recent advancements have illuminated the critical role of RNA modifications in post-
transcriptional regulation, shaping the landscape of gene expression. This review explores …

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs

MJ Yared, Y Yoluç, M Catala, C Tisné… - Nucleic Acids …, 2023 - academic.oup.com
As essential components of the protein synthesis machinery, tRNAs undergo a tightly
controlled biogenesis process, which include the incorporation of numerous …

ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

H Ohtsuka, Y Otsubo, T Shimasaki… - Molecular …, 2023 - Wiley Online Library
In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …