Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

MJ Peluso, D Ryder, RR Flavell, Y Wang… - Science translational …, 2024 - science.org
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …

The quest for cellular markers of HIV reservoirs: any color you like

G Darcis, B Berkhout, AO Pasternak - Frontiers in immunology, 2019 - frontiersin.org
Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV)
replication and improves immune function, but is unable to eradicate the virus. Therefore …

Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

J Cantero-Pérez, J Grau-Expósito… - Nature …, 2019 - nature.com
HIV viral reservoirs are established very early during infection. Resident memory T cells
(TRM) are present in tissues such as the lower female genital tract, but the contribution of …

[HTML][HTML] Multimodal molecular imaging reveals tissue-based T cell activation and viral RNA persistence for up to 2 years following COVID-19

MJ Peluso, D Ryder, R Flavell, Y Wang, J Levi… - Medrxiv, 2023 - ncbi.nlm.nih.gov
The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms
(Long COVID) following SARS-CoV-2 infection are incompletely understood. There is …

The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging players in viral persistence

A Astorga-Gamaza, MJ Buzon - Current Opinion in HIV and AIDS, 2021 - journals.lww.com
The active human immunodeficiency virus reservoir during ant... : Current Opinion in HIV and
AIDS The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging …

CD32+ CD4+ T cells are highly enriched for HIV DNA and can support transcriptional latency

G Darcis, NA Kootstra, B Hooibrink, T van Montfort… - Cell reports, 2020 - cell.com
The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as
marker of this reservoir has aroused much interest, but subsequent reports have challenged …

Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response

A Astorga-Gamaza, J Grau-Expósito, J Burgos… - Elife, 2022 - elifesciences.org
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous
cell reservoirs, which can be maintained by different mechanisms including cellular …

AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery

SA Theuerkauf, E Herrera-Carrillo, F John, LJ Zinser… - Biomaterials, 2023 - Elsevier
Precise delivery of genes to therapy-relevant cells is crucial for in vivo gene therapy.
Receptor-targeting as prime strategy for this purpose is limited to cell types defined by a …

[HTML][HTML] The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

HS Sperber, KA Raymond, MS Bouzidi, T Ma… - Cell reports, 2023 - cell.com
Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for
human immunodeficiency virus (HIV) infection. Here, we implement a systems approach to …

Eliminating the persistent HIV reservoir based on biomarker expression–how do we get there?

N Beliakova-Bethell - Virology, 2024 - Elsevier
Persistent HIV reservoir with different levels of proviral transcriptional activity represents a
hurdle to HIV cure. The absence of a specific molecular signature or a “biomarker” to define …