G Darcis, B Berkhout, AO Pasternak - Frontiers in immunology, 2019 - frontiersin.org
Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function, but is unable to eradicate the virus. Therefore …
HIV viral reservoirs are established very early during infection. Resident memory T cells (TRM) are present in tissues such as the lower female genital tract, but the contribution of …
MJ Peluso, D Ryder, R Flavell, Y Wang, J Levi… - Medrxiv, 2023 - ncbi.nlm.nih.gov
The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is …
A Astorga-Gamaza, MJ Buzon - Current Opinion in HIV and AIDS, 2021 - journals.lww.com
The active human immunodeficiency virus reservoir during ant... : Current Opinion in HIV and AIDS The active human immunodeficiency virus reservoir during antiretroviral therapy: emerging …
G Darcis, NA Kootstra, B Hooibrink, T van Montfort… - Cell reports, 2020 - cell.com
The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as marker of this reservoir has aroused much interest, but subsequent reports have challenged …
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular …
SA Theuerkauf, E Herrera-Carrillo, F John, LJ Zinser… - Biomaterials, 2023 - Elsevier
Precise delivery of genes to therapy-relevant cells is crucial for in vivo gene therapy. Receptor-targeting as prime strategy for this purpose is limited to cell types defined by a …
HS Sperber, KA Raymond, MS Bouzidi, T Ma… - Cell reports, 2023 - cell.com
Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for human immunodeficiency virus (HIV) infection. Here, we implement a systems approach to …
Persistent HIV reservoir with different levels of proviral transcriptional activity represents a hurdle to HIV cure. The absence of a specific molecular signature or a “biomarker” to define …