The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …

Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …

Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes,
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …

Breast cancer stem cells (CSCs) are thought to drive recurrence and metastasis. Their
identity has been linked to the epithelial to mesenchymal transition (EMT) but remains highly …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

Recent studies have boosted our understanding of long noncoding RNAs (lncRNAs) in
numerous biological processes, but few have examined their roles in somatic cell …

Oct4 is widely considered the most important among the four Yamanaka reprogramming
factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for …

Cellular heterogeneity in cancer represents a significant challenge. In order to develop
effective and lasting therapies, it is essential to understand the source of this heterogeneity …

Abstract Nuclear factor, erythroid 2-like 2 (Nrf2) is a master transcription factor for cellular
defense against endogenous and exogenous stresses by regulating expression of many …