Cardiac innervation and sudden cardiac death

K Fukuda, H Kanazawa, Y Aizawa, JL Ardell… - Circulation …, 2015 - Am Heart Assoc
Afferent and efferent cardiac neurotransmission via the cardiac nerves intricately modulates
nearly all physiological functions of the heart (chronotropy, dromotropy, lusitropy, and …

The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies

N Herring, M Kalla, DJ Paterson - Nature Reviews Cardiology, 2019 - nature.com
Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …

Autonomic modulation for cardiovascular disease

J Hadaya, JL Ardell - Frontiers in physiology, 2020 - frontiersin.org
Dysfunction of the autonomic nervous system has been implicated in the pathogenesis of
cardiovascular disease, including congestive heart failure and cardiac arrhythmias. Despite …

Heart–brain axis: effects of neurologic injury on cardiovascular function

P Tahsili-Fahadan, RG Geocadin - Circulation research, 2017 - Am Heart Assoc
A complex interaction exists between the nervous and cardiovascular systems. A large
network of cortical and subcortical brain regions control cardiovascular function via the …

[HTML][HTML] Exercise training-induced modification in autonomic nervous system: An update for cardiac patients

F Besnier, M Labrunee, A Pathak… - Annals of physical and …, 2017 - Elsevier
Patients with cardiovascular disease show autonomic dysfunction, including sympathetic
activation and vagal withdrawal, which leads to fatal events. This review aims to place …

Efficacy of stellate ganglion blockade in managing electrical storm: a systematic review

L Meng, CH Tseng, K Shivkumar, O Ajijola - JACC: Clinical …, 2017 - jacc.org
Objectives: The study sought to characterize the efficacy of stellate ganglion block (SGB) as
a treatment for electrical storm (ES). Background: The efficacy of percutaneous SGB for …

Translational neurocardiology: preclinical models and cardioneural integrative aspects

JL Ardell, MC Andresen, JA Armour… - The Journal of …, 2016 - Wiley Online Library
Neuronal elements distributed throughout the cardiac nervous system, from the level of the
insular cortex to the intrinsic cardiac nervous system, are in constant communication with …

A Pooled Analysis of Multicenter Cohort Studies of 123I-mIBG Imaging of Sympathetic Innervation for Assessment of Long-Term Prognosis in Heart Failure

T Nakata, K Nakajima, S Yamashina, T Yamada… - JACC: Cardiovascular …, 2013 - jacc.org
Objectives: The study objectives were to create a cardiac metaiodobenzylguanidine (m IBG)
database using multiple prospective cohort studies and to determine the quantitative iodine …

Defining the neural fulcrum for chronic vagus nerve stimulation: implications for integrated cardiac control

JL Ardell, H Nier, M Hammer… - The Journal of …, 2017 - Wiley Online Library
Key points The evoked cardiac response to bipolar cervical vagus nerve stimulation (VNS)
reflects a dynamic interaction between afferent mediated decreases in central …

Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system

PS Rajendran, K Nakamura, OA Ajijola… - The Journal of …, 2016 - Wiley Online Library
Key points Intrinsic cardiac (IC) neurons undergo differential morphological and phenotypic
remodelling that reflects the site of myocardial infarction (MI). Afferent neural signals from the …