Invasive infection caused by Candida species is a condition associated with medical
progress. It is a common health care–associated infection (HAI), and is widely recognized as …

The epidemiology of invasive candidiasis has evolved in recent years, warranting a review
of the changes and the implications for current and future diagnosis and treatment. The …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background The emergence of antifungal resistance threatens effective treatment of
invasive fungal infection (IFI). Invasive candidiasis is the most common health care …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Background Current guidelines recommend empirical antifungal therapy in patients with
sepsis with high risk of invasive Candida infection. However, many different risk factors have …

Invasive infection due to Candida species is a condition associated with medical progress. It
is a common health care–associated infection and is widely recognized as a major cause of …

Abstract (See the Editorial Commentary by Clancy and Nguyen, on pages 1123–5.)
Background. Invasive candidiasis (IC) is an important healthcare-related infection, with …