Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction
The first paradigm of plant breeding involves direct selection-based phenotypic observation,
followed by predictive breeding using statistical models for quantitative traits constructed …
followed by predictive breeding using statistical models for quantitative traits constructed …
The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements …
associated with human complex traits. However, the genes or functional DNA elements …
[图书][B] Mendelian randomization: methods for using genetic variants in causal estimation
S Burgess, SG Thompson - 2015 - books.google.com
Presents the Terminology and Methods of Mendelian Randomization for Epidemiological
StudiesMendelian randomization uses genetic instrumental variables to make inferences …
StudiesMendelian randomization uses genetic instrumental variables to make inferences …
Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
Learning from co-expression networks: possibilities and challenges
EAR Serin, H Nijveen, HWM Hilhorst… - Frontiers in plant …, 2016 - frontiersin.org
Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …
organization, function and evolution of plant genes is essential to disentangle important …
Phenomics: the next challenge
A key goal of biology is to understand phenotypic characteristics, such as health, disease
and evolutionary fitness. Phenotypic variation is produced through a complex web of …
and evolutionary fitness. Phenotypic variation is produced through a complex web of …
The genetics of quantitative traits: challenges and prospects
TFC Mackay, EA Stone, JF Ayroles - Nature Reviews Genetics, 2009 - nature.com
A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …
quantitative traits. We review the principles of quantitative trait locus mapping and …
Heritability in the genomics era—concepts and misconceptions
PM Visscher, WG Hill, NR Wray - Nature reviews genetics, 2008 - nature.com
Heritability allows a comparison of the relative importance of genes and environment to the
variation of traits within and across populations. The concept of heritability and its definition …
variation of traits within and across populations. The concept of heritability and its definition …
Comparative analysis of proteome and transcriptome variation in mouse
The relationships between the levels of transcripts and the levels of the proteins they encode
have not been examined comprehensively in mammals, although previous work in plants …
have not been examined comprehensively in mammals, although previous work in plants …