ABSTRACT p27Kip1 was first discovered as a key regulator of cell proliferation. The
canonical function of p27Kip1 is inhibition of cyclin-dependent kinase (CDK) activity. In …

Abstract The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is a major regulator of
metabolism, migration, survival, proliferation, and antiviral immunity. Both an overactivation …

Epithelial ovarian cancer (EOC) is an infrequent but highly lethal disease, almost invariably
treated with platinum‐based therapies. Improving the response to platinum represents a …

The CDKN1B gene encodes for the p27Kip1 protein, firstly characterized as a cyclin
dependent kinase (CDK)-inhibitor. Germline CDKN1B pathogenic variants have been …

The asymptomatic nature of cholangiocarcinoma (CCA), particularly during its early stages,
in combination with its high aggressiveness and chemoresistance, significantly …

Abstract Background Bexarotene (Targretin®) is currently the only FDA approved retinoid X
receptor (RXR)–selective agonist for the treatment of cutaneous T-cell lymphomas (CTCLs) …

Post-translational modifications (PTMs) such as phosphorylation, acetylation, methylation,
ubiquitylation, sumoylation are important mechanisms to regulate functions of different …

Background Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and
poor response to conventional therapies. Previously, we found that p27kip1 nuclear …

Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL)
gene-rearranged acute lymphoblastic leukemia (MLL+ ALL) with a dismal prognosis. We …

Among the hallmarks of cholangiocarcinoma (CCA) progression and unresponsiveness to
therapy is impaired ubiquitin-dependent degradation of nuclear tumor suppressor protein. In …