Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines

VV Dotsenko, DS Buryi, DY Lukina… - Russian Chemical …, 2020 - Springer
Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines
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Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies

SMH Sanad, AEM Mekky - Journal of the Iranian Chemical Society, 2021 - Springer
Alzheimer's disease is a degenerative brain condition that is the leading cause of dementia
affecting millions of people around the world. Therapeutic development has focused on the …

Regioselective synthesis and theoretical calculations of bis (pyrido [2′, 3′: 3, 4] pyrazolo [1, 5-a] pyrimidines) linked to benzofuran units via piperazine spacer: a …

SMH Sanad, MSM Ahmed, AEM Mekky… - Journal of Molecular …, 2021 - Elsevier
Bis (enaminone), linked to benzofuran units via piperazine spacer, was prepared and used
as a key intermediate in this study. It reacted for 8 h at reflux with two equivalents of 2 …

Regioselective synthesis of novel antibacterial pyrazole-benzofuran hybrids: 2D NMR spectroscopy studies and molecular docking

SMH Sanad, DH Hanna, AEM Mekky - Journal of Molecular Structure, 2019 - Elsevier
The acetyl derivative bearing benzofuran moiety, its enaminone and different hydrazines are
used as synthons for the regioselective synthesis of substituted pyrazoles. Their structures …

New piperazine-based bis(thieno[2,3-b]pyridine) and bis(pyrazolo[3,4-b]pyridine) hybrids linked to benzofuran units: Synthesis and in vitro screening of potential …

AAM Ahmed, AEM Mekky… - Synthetic Communications, 2022 - Taylor & Francis
Two series of piperazine-based bis (thieno [2, 3-b] pyridines) and bis (pyrazolo [3, 4-b]
pyridines) were prepared, in good yields, utilizing the appropriate bis (pyridinethione). The …

Pyridine‐2(1H)‐thiones: Versatile Precursors for Novel Pyrazolo[3,4‐b]pyridine, Thieno[2,3‐b]pyridines, and Their Fused Azines

SMH Sanad, AM Abdel‐Fattah… - Journal of …, 2019 - Wiley Online Library
Pyridine‐2 (1H)‐thiones were prepared and reacted with several active halogenated
reagents to afford novel thieno [2, 3‐b] pyridines in excellent yields. Thieno [2, 3‐b] pyridine …

Synthesis of novel bis(chromenes) and bis(chromeno[3,4-C]pyridine) incorporating piperazine moiety

AEM Mekky, SMH Sanad - Synthetic Communications, 2019 - Taylor & Francis
Abstract Novel bis (2-oxo-2 H-chromene) as well as bis (2-imino-2 H-chromene) derivatives
incorporating piperazine moiety were prepared by the cyclocondensation reaction of bis (2 …

Bis(benzofuran-enaminone) hybrid possessing piperazine linker: Versatile precursor for microwave assisted synthesis of bis(pyrido[2',3':3,4]pyrazolo[1,5-a] …

AEM Mekky, MSM Ahmed, SMH Sanad… - Synthetic …, 2021 - Taylor & Francis
We reported herein efficient procedures for the synthesis of new piperazine-linked bis
(pyrido [2', 3': 3, 4] pyrazolo [1, 5-a] pyrimidines) using bis (benzofuran-enaminone) hybrid …

Synthesis, characterization, and antimicrobial evaluation of novel thiohydrazonates and pyrazolo [3, 4-b] pyridines

AEM Mekky, SMH Sanad - Polycyclic Aromatic Compounds, 2021 - Taylor & Francis
Diphenyl-1H-pyrazole-4-carbaldehyde and cyanothioacetamide were used to prepare the 2-
thioxo-1, 2-dihydropyridine-3-carbonitrile derivative, in a good yield, and taken as synthetic …

Ultrasound‐Mediated Synthesis of New (Piperazine‐Chromene)‐Linked Bis(thieno[2,3‐b]pyridine) Hybrids as Potential Anti‐acetylcholinesterase

SMH Sanad, AEM Mekky - ChemistrySelect, 2022 - Wiley Online Library
Using ultrasound irradiation and the eco‐friendly piperazine, two series of (piperazine‐
chromene)‐linked bis (thieno [2, 3‐b] pyridine) hybrids attached to various arene or …