Epidermal growth factor receptor-mutated non-small-cell lung cancer: A primer on contemporary management
Non-small-cell lung cancer (NSCLC) constitutes 85% of patients diagnosed with lung
cancer. In metastatic cases, its treatment classically consists of systemic cytotoxic …
cancer. In metastatic cases, its treatment classically consists of systemic cytotoxic …
MRI‐based radiomics analysis for predicting the EGFR mutation based on thoracic spinal metastases in lung adenocarcinoma patients
M Ren, H Yang, Q Lai, D Shi, G Liu, X Shuang… - Medical …, 2021 - Wiley Online Library
Purpose This study aims to develop and evaluate multi‐parametric MRI‐based radiomics for
preoperative identification of epidermal growth factor receptor (EGFR) mutation, which is …
preoperative identification of epidermal growth factor receptor (EGFR) mutation, which is …
Update on EGFR Mutational Testing and the Potential of Noninvasive Liquid Biopsy in Non–Small-cell Lung Cancer
E Kim, R Feldman, II Wistuba - Clinical Lung Cancer, 2018 - Elsevier
Mutations in the epidermal growth factor receptor (EGFR) are important drivers of non–small-
cell lung cancer (NSCLC) and have led to the emergence of EGFR-targeted therapies as …
cell lung cancer (NSCLC) and have led to the emergence of EGFR-targeted therapies as …
[HTML][HTML] Forensic tri-allelic SNP genotyping using nanopore sequencing
S Cornelis, Y Gansemans, AS Vander Plaetsen… - Forensic Science …, 2019 - Elsevier
The potential and current state-of-the-art of forensic SNP genotyping using nanopore
sequencing was investigated with a panel of 16 tri-allelic single nucleotide polymorphisms …
sequencing was investigated with a panel of 16 tri-allelic single nucleotide polymorphisms …
A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1 and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3
T Sakane, T Murase, K Okuda, K Saida… - …, 2019 - Wiley Online Library
Aims Thymic carcinoma is rare and usually has a fatal outcome. Gene mutations in the
epidermal growth factor receptor (EGFR) signalling pathway and TP53 have not been well …
epidermal growth factor receptor (EGFR) signalling pathway and TP53 have not been well …
Acidic extracellular environment affects miRNA expression in tumors in vitro and in vivo
A Riemann, S Reime, O Thews - International Journal of …, 2019 - Wiley Online Library
Hypoxia can control the expression of miRNAs in tumors which play an important role for the
control of the malignant behavior. The aim of the study was to analyze whether extracellular …
control of the malignant behavior. The aim of the study was to analyze whether extracellular …
A dual-functional microfluidic chip for guiding personalized lung cancer medicine: combining EGFR mutation detection and organoid-based drug response test
K Zhang, J Xi, H Zhao, Y Wang, J Xue, N Liang, Z Wei - Lab on a Chip, 2024 - pubs.rsc.org
Many efforts have been paid to advance the effectiveness of personalized medicine for lung
cancer patients. Sequencing-based molecular diagnosis of EGFR mutations has been …
cancer patients. Sequencing-based molecular diagnosis of EGFR mutations has been …
[HTML][HTML] CRISPR-Cas technology in forensic investigations: principles, applications, and ethical considerations
AF Sobral, RJ Dinis-Oliveira, DJ Barbosa - Forensic Science International …, 2024 - Elsevier
Abstract CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats and
CRISPR-associated proteins) systems are adaptive immune systems originally present in …
CRISPR-associated proteins) systems are adaptive immune systems originally present in …
[HTML][HTML] Multiplex Snapshot minisequencing for the detection of common PAH gene mutations in Iranian patients with Phenylketonuria
PN Aligoodarzi, G Rostami, SRK Nezhad… - Iranian biomedical …, 2023 - ncbi.nlm.nih.gov
Background: Phenylketonuria is a common inborn defect of amino acid metabolism in the
world. This failure is caused by an autosomal recessive insufficiency of the hepatic enzyme …
world. This failure is caused by an autosomal recessive insufficiency of the hepatic enzyme …
Low tumour cell content in a lung tumour bank: implications for molecular characterisation
F Goh, EE Duhig, BE Clarke, E McCaul, L Passmore… - Pathology, 2017 - Elsevier
Lung cancer encompasses multiple malignant epithelial tumour types, each with specific
targetable, potentially actionable mutations, such that precision management mandates …
targetable, potentially actionable mutations, such that precision management mandates …