Immune checkpoint inhibitors are reshaping the prognosis of many cancer and are
progressively becoming the standard of care in the treatment of many tumour types …

The inflammatory process plays a central role in the development and progression of
numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune …

Insights into the pathophysiology of autoimmune inflammatory diseases including psoriasis
have advanced considerably in recent years, and in parallel, so too have the available …

Background Data on the long‐term administration of ustekinumab in recommended doses
are limited. Aim To assess the real‐world, long‐term effectiveness of ustekinumab in …

The development of biologics and small oral molecules has recently changed the scenario
of pharmacologic treatment of systemic rheumatic diseases and it has become a real …

The pharmacological management of inflammatory bowel disease (IBD) over the last two
decades has transitioned from reliance on aminosalycilates, corticosteroids and …

Interleukin-23 (IL-23) is a proinflammatory cytokine produced mainly by macrophages and
antigen-presenting cells (APCs) after antigenic stimulation. IL-23 plays a significant role as a …

Background Ustekinumab [UST] is effective in the treatment of adults with moderate to
severe Crohn's disease [CD]. There is a paucity of data on its use in children. Aim To …

Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease - Gastroenterology Clinics
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The pharmacotherapy of inflammatory bowel diseases (Crohn's disease and ulcerative
colitis) has experienced significant progress with the advent of monoclonal antibodies …