Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer
through plasmids plays a major role. The identification of plasmid characteristics and their …

Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in
the 2000s as important human pathogens, have spread extensively throughout the world …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA.
Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred …

CTX-M β-lactamases are considered a paradigm in the evolution of a resistance
mechanism. Incorporation of different chromosomal bla CTX-M related genes from different …

The management of infections due to Klebsiella pneumoniae has been complicated by the
emergence of antimicrobial resistance, especially to carbapenems. Resistance to …

Hypervirulent Klebsiella pneumoniae (hvKP) is traditionally defined by hypermucoviscosity,
but data based on genetic background are limited. Antimicrobial-resistant hvKP has been …

Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-
associated commensal microbiomes, but they can also cause a wide range of infections that …