The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

The T cell compartment can form a powerful defense against extrinsic (eg, pathogens) and
intrinsic danger (eg, malignant cells). At the same time, specific subsets of T cells control this …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

The molecular interactions provided by the thymic microenvironment that predicate T cell
development remain obscure. Here, we show that a bone marrow stromal cell line …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

Lympho–stromal interactions in multiple microenvironments within the thymus have a crucial
role in the regulation of T-cell development and selection. Recent studies have implicated …

The thymus represents an epithelial–mesenchymal tissue, anatomically structured into
discrete cortical and medullary regions that contain phenotypically and functionally distinct …

In bone marrow, hematopoiesis is thought to depend on special microenvironments known
as niches that maintain blood cells. However, the identity of niches and interaction of blood …