Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Recently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants continuously emerged and posed a major threat to global public health. Among …
2) variants continuously emerged and posed a major threat to global public health. Among …
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters
M Sasaki, K Tabata, M Kishimoto, Y Itakura… - Science translational …, 2022 - science.org
In parallel with vaccination, oral antiviral agents are highly anticipated to act as
countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic …
countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic …
[HTML][HTML] Reverse genetics systems for SARS-CoV-2: Development and applications
HL Cai, YW Huang - Virologica Sinica, 2023 - Elsevier
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
caused serious harm to human health and struck a blow to global economic development …
caused serious harm to human health and struck a blow to global economic development …
Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters
Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines are in pre-clinical or clinical development. We seek to attenuate SARS-CoV-2 …
vaccines are in pre-clinical or clinical development. We seek to attenuate SARS-CoV-2 …
Evolution of ACE2-independent SARS-CoV-2 infection and mouse adaption after passage in cells expressing human and mouse ACE2
Human ACE2 Human angiotensin converting enzyme 2 (hACE2) is the key cell attachment
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …
A non-transmissible live attenuated SARS-CoV-2 vaccine
JM Adler, RM Vidal, A Voß, S Kunder, M Nascimento… - Molecular Therapy, 2023 - cell.com
Live attenuated vaccines (LAVs) administered via the mucosal route may offer better control
of the COVID-19 pandemic than non-replicating vaccines injected intramuscularly …
of the COVID-19 pandemic than non-replicating vaccines injected intramuscularly …
Could a lower toll-like receptor (TLR) and NF-κB activation due to a changed charge distribution in the spike protein be the reason for the lower pathogenicity of …
R Kircheis, O Planz - International Journal of Molecular Sciences, 2022 - mdpi.com
The novel SARS-CoV-2 Omicron variant B. 1.1. 529, which emerged in late 2021, is
currently active worldwide, replacing other variants, including the Delta variant, due to an …
currently active worldwide, replacing other variants, including the Delta variant, due to an …
The reassessed potential of SARS-CoV-2 attenuation for COVID-19 vaccine development—A systematic review
M Goławski, P Lewandowski, I Jabłońska, M Delijewski - Viruses, 2022 - mdpi.com
Live-attenuated SARS-CoV-2 vaccines received relatively little attention during the COVID-
19 pandemic. Despite this, several methods of obtaining attenuated coronaviruses are …
19 pandemic. Despite this, several methods of obtaining attenuated coronaviruses are …
The role of Notch signaling pathway in metabolic bone diseases
Y Gao, Z Fu, J Guan, X Liu, Q Zhang - Biochemical Pharmacology, 2023 - Elsevier
Metabolic bone diseases is the third most common endocrine diseases after diabetes and
thyroid diseases. More than 500 million people worldwide suffer from metabolic bone …
thyroid diseases. More than 500 million people worldwide suffer from metabolic bone …
Comparison of mutations in human parainfluenza viruses during passage in primary human bronchial/tracheal epithelial air-liquid interface cultures and cell lines
S Sugimoto, M Kawase, R Suwa, Y Kume… - Microbiology …, 2024 - journals.asm.org
Human parainfluenza virus (HPIV) causes respiratory infections, which are exacerbated in
children and older people. Correct evaluation of viral characteristics is essential for the study …
children and older people. Correct evaluation of viral characteristics is essential for the study …