Innate immune responses play a critical role in controlling acute infections due to
Pseudomonas aeruginosa in both mice and in humans. In this review we focus on innate …

Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for a high
incidence of acute and chronic pulmonary infection. These infections are particularly …

Upon detection of pathogen-associated molecular patterns, innate immune receptors initiate
inflammatory responses. These receptors include cytoplasmic NOD-like receptors (NLRs) …

The respiratory tract is exceptionally well defended against infection from inhaled bacteria,
with multiple proinflammatory signaling cascades recruiting phagocytes to clear airway …

Pseudomonas aeruginosa is an opportunistic pathogen that can cause critical cellular
damage and subvert the immune response to promote its survival. Among the numerous …

The opportunistic human pathogen Pseudomonas aeruginosa causes rapidly progressive
and tissue-destructive infections, such as hospital-acquired and ventilator-associated …

Pseudomonas aeruginosa possesses a type III secretion system (T3SS) to intoxicate host
cells and evade innate immunity. This virulence-related machinery consists of a molecular …

Immune recognition of pathogen-associated ligands leads to assembly and activation of
inflammasomes, resulting in the secretion of inflammatory cytokines IL-1β and IL-18 and an …

The type III secretion system (T3SS) is a complex nanomachine of many pathogenic Gram-
negative bacteria. It forms a proteinaceous channel that is inserted into the host eukaryotic …

The opportunistic pathogen Pseudomonas aeruginosa expresses a type 3 secretion system
(T3SS) strongly associated with bacterial virulence in murine models and human patients …