Paraoxonase and atherosclerosis
PN Durrington, B Mackness… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …
Pharmacogenetics of paraoxonases: a brief review
DI Draganov, BN La Du - Naunyn-Schmiedeberg's archives of …, 2004 - Springer
The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and
PON3, aligned next to each other on chromosome 7. By far the most-studied member of the …
PON3, aligned next to each other on chromosome 7. By far the most-studied member of the …
HDL and arteriosclerosis: beyond reverse cholesterol transport
JR Nofer, B Kehrel, M Fobker, B Levkau, G Assmann… - Atherosclerosis, 2002 - Elsevier
The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol
and the risk of coronary heart disease, the protection of susceptible animals from …
and the risk of coronary heart disease, the protection of susceptible animals from …
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density …
CJ Ng, DJ Wadleigh, A Gangopadhyay, S Hama… - Journal of biological …, 2001 - ASBMB
The oxidation of apolipoprotein B-containing lipoproteins and cell membrane lipids is
believed to play an integral role in the development of fatty streak lesions, an initial step in …
believed to play an integral role in the development of fatty streak lesions, an initial step in …
Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids
ST Reddy, DJ Wadleigh, V Grijalva, C Ng… - … , and vascular biology, 2001 - Am Heart Assoc
Paraoxonase-1 (PON1) is a secreted protein associated primarily with high density
lipoprotein (HDL) and participates in the prevention of low density lipoprotein (LDL) …
lipoprotein (HDL) and participates in the prevention of low density lipoprotein (LDL) …
Insulin resistance syndrome (metabolic syndrome) and obesity in Asian Indians: evidence and implications
A Misra, NK Vikram - Nutrition, 2004 - Elsevier
OBJECTIVES: This review describes prevalence, determinants, and possible
pathophysiologic mechanisms and suggests management and research directions for …
pathophysiologic mechanisms and suggests management and research directions for …
Human paraoxonase-2 (PON2): protein functions and modulation
G Manco, E Porzio, TM Carusone - Antioxidants, 2021 - mdpi.com
PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …
Human Serum Paraoxonase/Arylesterase's Retained Hydrophobic N-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids: Apolipoprotein AI …
RC Sorenson, CL Bisgaier, M Aviram… - … , and vascular biology, 1999 - Am Heart Assoc
In serum, human paraoxonase/arylesterase (PON1) is found exclusively associated with
high density lipoprotein (HDL) and contributes to its antiatherogenic properties by inhibiting …
high density lipoprotein (HDL) and contributes to its antiatherogenic properties by inhibiting …
The paraoxonases: role in human diseases and methodological difficulties in measurement
Research into the paraoxonase (PON) gene family has flourished over the past few years. In
the 1970s and 1980s, only PON1 was known, and the investigations were conducted …
the 1970s and 1980s, only PON1 was known, and the investigations were conducted …
The paraoxonase gene family and atherosclerosis
CJ Ng, DM Shih, SY Hama, N Villa, M Navab… - Free radical biology and …, 2005 - Elsevier
Epidemiologic, genetic, and biochemical studies support an antiatherogenic role for
paraoxonase (PON) 1. While the precise mechanism by which PON1 protects against the …
paraoxonase (PON) 1. While the precise mechanism by which PON1 protects against the …