Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Over the past decade, theranostic imaging has emerged as a powerful clinical tool in
oncology for identifying patients likely to respond to targeted therapies and for monitoring …

The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Nuclear medicine is defined as the use of radionuclides for diagnostic and therapeutic
applications. The imaging modalities positron emission tomography (PET) and single …

Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …

Radioimmunotherapy (RIT) is FDA-approved for the clinical management of liquid
malignancies, however, its use for solid malignancies remains a challenge. The putative …

Tetrazine ligation has gained interest as a bio-orthogonal chemistry tool within the last
decade. In nuclear medicine, tetrazine ligation is currently being explored for pretargeted …