Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer

CM Rudin, M Reck, ML Johnson, F Blackhall… - Journal of Hematology & …, 2023 - Springer
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a poor
prognosis. Initial responses to standard-of-care chemo-immunotherapy are, unfortunately …

Combining chemotherapy with CAR-T cell therapy in treating solid tumors

AX Wang, XJ Ong, C D'Souza, PJ Neeson… - Frontiers in …, 2023 - frontiersin.org
Chemotherapy has long been a standard treatment for a wide range of malignancies, where
patients typically undergo multiple rounds of chemotherapy regimens to control tumor …

Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non–small cell lung cancer

BH Herzog, JM Baer, N Borcherding… - Science translational …, 2023 - science.org
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune
checkpoint blockade has improved survival for many patients with NSCLC, but most fail to …

Secondary immunodeficiency in hematological malignancies: focus on multiple myeloma and chronic lymphocytic leukemia

A Allegra, A Tonacci, C Musolino, G Pioggia… - Frontiers in …, 2021 - frontiersin.org
Secondary immunodeficiency is reported in most patients with hematological malignancies
such as chronic lymphocytic leukemia and multiple myeloma. The aim of our review was to …

Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

A Arana Echarri, L Struszczak, M Beresford… - Frontiers in …, 2023 - frontiersin.org
Methods: We examined whether immune cell profiles differ between healthy women (n= 38)
and breast cancer survivors (n= 27) within 2 years of treatment, and whether any group …

Targeting the dendritic cell-T cell axis to develop effective immunotherapies for glioblastoma

B Gardam, T Gargett, MP Brown, LM Ebert - Frontiers in Immunology, 2023 - frontiersin.org
Glioblastoma is an aggressive primary brain tumor that has seen few advances in treatments
for over 20 years. In response to this desperate clinical need, multiple immunotherapy …

Can immunotherapy reinforce chemotherapy efficacy? a new perspective on colorectal cancer treatment

X He, H Lan, K Jin, F Liu - Frontiers in Immunology, 2023 - frontiersin.org
As one of the main threats to human life (the fourth most dangerous and prevalent cancer),
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with chemotherapy

N Rizvi, FO Ademuyiwa, ZA Cao, HX Chen… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Although immunotherapy can offer profound clinical benefit for patients with a variety of
difficult-to-treat cancers, many tumors either do not respond to upfront treatment with …

[HTML][HTML] Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

Y Chang, M Chang, X Bao, C Dong - Bioactive materials, 2024 - Elsevier
Adoptive immunotherapy, notably involving chimeric antigen receptor (CAR)-T cells, has
obtained Food and Drug Administration (FDA) approval as a treatment for various …

Chemotherapy reinforces anti-tumor immune response and enhances clinical efficacy of immune checkpoint inhibitors

L Zhang, C Zhou, S Zhang, X Chen, J Liu, F Xu… - Frontiers in …, 2022 - frontiersin.org
New evidence suggests that the clinical success of chemotherapy is not merely due to tumor
cell toxicity but also arises from the restoration of immunosurveillance, which has been …