The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Microglia constantly survey the brain microenvironment and rapidly adopt different
phenotypes in response to environmental stimuli. Such dynamic functions require a unique …

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …

Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a
critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR …

Resistance to gemcitabine in pancreatic ductal adenocarcinoma (PDAC) leads to ineffective
chemotherapy and, consequently, delayed treatment, thereby contributing to poor prognosis …

Pharmacological treatment of colorectal carcinoma currently proceeds through the
administration of a combination of different chemotherapeutic agents. In the case of rectal …

Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence
indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate …

Summary mTORC1 regulates cellular growth and is activated by growth factors and by
essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc …