Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

β-Nucleosides are fundamental building blocks of biological systems and are widely used
as therapeutic agents for the treatment of cancer and viral infections, among others. In the …

Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other
molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of …

Directed enzyme prodrug therapy (DEPT) strategies show promise in mitigating
chemotherapy side effects during cancer treatment. Among these, the use of immobilized …

The use of enzymes for the synthesis of nucleoside analogues offers several advantages
over multistep chemical methods, including chemo‐, regio‐and stereoselectivity as well as …

One of the major drawbacks of the industrial implementation of enzymatic processes is the
low operational stability of the enzymes under tough industrial conditions. In this respect, the …

Enzyme-mediated processes have proven to be a valuable and sustainable alternative to
traditional chemical methods. In this regard, the use of multi-enzymatic systems enables the …

Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases,
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …

Biocatalysis reproduce nature's synthetic strategies in order to synthesize different organic
compounds. Natural metabolic pathways usually involve complex networks to support …

The review systematically covers experimental data on the synthesis of modified
benzimidazole nucleosides and evaluation of their biological activity published mainly over …