3D printing technologies in personalized medicine, nanomedicines, and biopharmaceuticals

DR Serrano, A Kara, I Yuste, FC Luciano, B Ongoren… - Pharmaceutics, 2023 - mdpi.com
3D printing technologies enable medicine customization adapted to patients' needs. There
are several 3D printing techniques available, but majority of dosage forms and medical …

The functional and clinical roles of liquid biopsy in patient-derived models

Z Zhu, E Hu, H Shen, J Tan, S Zeng - Journal of Hematology & Oncology, 2023 - Springer
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

Global Literature Analysis of Organoid and Organ‐on‐Chip Research

J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2024 - Wiley Online Library
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

FA Yousef Yengej, J Jansen… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

Advances in microfluidic technologies in organoid research

H Liu, Z Gan, X Qin, Y Wang… - Advanced Healthcare …, 2024 - Wiley Online Library
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …

Developing liver microphysiological systems for biomedical applications

J Wang, X Wu, J Zhao, H Ren… - Advanced Healthcare …, 2024 - Wiley Online Library
Microphysiological systems (MPSs), also known as organ chips, are micro‐units that
integrate cells with diverse physical and biochemical environmental cues. In the field of liver …

From organ-on-a-chip to human-on-a-chip: A review of research progress and latest applications

Y Huang, T Liu, Q Huang, Y Wang - ACS sensors, 2024 - ACS Publications
Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and
functionality of human organs on a microfluidic chip, is undergoing significant technological …

Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

FAY Yengej, CP Casellas, CME Ammerlaan… - Cell Reports, 2024 - cell.com
Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …

Mesenchymal stromal cell-derived extracellular vesicles for vasculopathies and angiogenesis: therapeutic applications and optimization

Y Zhu, ZF Liao, MH Mo, XD Xiong - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs), as part of the cellular secretome, have emerged as essential
cell–cell communication regulators in multiple physiological and pathological processes …

[HTML][HTML] Organ-on-a-chip: an emerging research platform

R Nithin, A Aggarwal, AB Sravani, P Mallya… - Organogenesis, 2023 - ncbi.nlm.nih.gov
In drug development, conventional preclinical and clinical testing stages rely on cell cultures
and animal experiments, but these methods may fall short of fully representing human …