Mammalian mitochondria contain a circular genome (mtDNA) which encodes subunits of the
oxidative phosphorylation machinery. The replication and maintenance of mtDNA is carried …

The homodimeric PolG2 accessory subunit of the mitochondrial DNA polymerase gamma
(Pol γ) enhances DNA binding and processive DNA synthesis by the PolG catalytic subunit …

DNA repair pathways are tightly regulated processes that recognize specific hallmarks of
DNA damage and coordinate lesion repair through discrete mechanisms, all within the …

Twinkle is a mitochondrial replicative helicase which can self-load onto and unwind
mitochondrial DNA. Nearly 60 mutations on Twinkle have been linked to human …

The mitochondrial single-stranded DNA (ssDNA) binding protein, mtSSB or SSBP1, binds to
ssDNA to prevent secondary structures of DNA that could impede downstream replication or …

Twinkle is the mammalian helicase vital for replication and integrity of mitochondrial DNA.
Over 90 Twinkle helicase disease variants have been linked to progressive external …

Because of their stable orientations and their minimal interference with native DNA
interactions and folding, emissive isomorphic nucleoside analogues are versatile tools for …

A multitude of different types of lesions is continuously introduced into the DNA inside our
cells, and their rapid and efficient repair is fundamentally important for the maintenance of …

旨在通过预测分析和亚细胞定位研究非洲猪瘟病毒(ASFV) D1133L 基因结构,
亚细胞定位与功能间的关系. 作者使用Mega6. 0 软件绘制了7 株不同基因型的D1133L …

The replisome is the multiprotein molecular machinery that replicates DNA. The replisome
components work in precise coordination to unwind the double helix of the DNA and …