It is now clearly established that complex interactions between genes and environment are
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …

Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to
accommodate to patterns of electrical activity. One component of these long-term changes is …

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors
have opposite effects on CREB (cAMP response element binding protein) function, gene …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …

Protein-protein interactions and calcium entry through the N-methyl-d-aspartate (NMDA)–
type glutamate receptor regulate synaptic development and plasticity in the central nervous …

Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-
nucleus communication and calcium signals in the cell nucleus. Here we show that in …

NMDA receptors promote neuronal survival but also cause cell degeneration and neuron
loss. The mechanisms underlying these opposite effects on neuronal fate are unknown …

During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …

Traditional techniques for investigating cultured neural networks, such as the patch clamp
and multi-electrode array, are limited by:(1) the number of identified cells which can be …