Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

The resurgence of concern about tuberculosis has resulted in the discovery that
Mycobacterium tuberculosis, a facultative intracellular pathogen, has developed numerous …

TNF and lymphotoxin-α (LTα) may act at various stages of the host response to
Mycobacterium tuberculosis. To dissect the effects of TNF independent of LTα, we have …

The mammalian innate immune system retains from Drosophila a family of homologous Toll-
like receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 …

We have used the cryosection immunogold technique to study the composition of the
Mycobacterium tuberculosis phagosome. We have used quantitative immunogold staining to …