In vivo, antibiotics are often much less efficient than ex vivo and relapses can occur. The
reasons for poor in vivo activity are still not completely understood. We have studied the …

Natural microbial populations often have complex spatial structures. This can impact their
evolution, in particular the ability of mutants to take over. While mutant fixation probabilities …

We consider a stochastic model of population dynamics where each individual is
characterised by a trait in {0, 1,..., L} and has a natural reproduction rate, a logistic death rate …

Investigating the emergence of a particular cell type is a recurring theme in models of
growing cellular populations. The evolution of resistance to therapy is a classic example …

A mutator is a variant in a population of organisms whose mutation rate is higher than the
average mutation rate in the population. For genetic and population dynamics reasons …

The recurrent exposure to herbicides in agricultural landscapes forces weeds to adapt in a
race against extinction. What role newly arising mutations and pre-existing variation play in …

En este trabajo presentamos un par de modelos nuevos para simular la dinámica fenotípica
en células bajo la hipótesis del fenotipo mutador. Ambos modelos dependen fuertemente …

The forest of mutations associated to a multitype branching forest is obtained by merging
together all vertices in each of its clusters and by preserving connections between …

Cette thèse est principalement consacrée à l'étude de quelques caractéristiques d'une
population à plusieurs types d'individus qui évolue selon un modèle de branchement multi …