Cardiac remodeling is generally accepted as a determinant of the clinical course of heart
failure (HF). Defined as genome expression resulting in molecular, cellular and interstitial …

increase in ratio of angiotensin II AT2 to AT1 receptor subtypes). Some of these switches,
such as the increased expression of the slow myosin ATPase isoform-myosin heavy chain …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Aims Biomarkers are increasingly being used in the management of patients with chronic
heart failure (HF). Galectin-3 is a recently developed biomarker associated with fibrosis and …

Background Despite the clinical importance of atrial fibrillation (AF), the development of
chronic nonvalvular AF models has been difficult. Animal models of sustained AF have been …

Collagen plays a vital role in maintaining structural integrity and in determining tissue
function. Therefore, methods to detect, quantify, and analyze collagen are valuable …

Unlike the non-renin-dependent hypertension associated with infrarenal aorta banding, an
abnormal accumulation of fibrillar collagen occurs within the adventitia of intramural …

Myocardial injury induces significant changes in ventricular structure and function at both the
cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure …

Myocardial fibrosis is associated with an activated renin-angiotensin-aldosterone system
(RAAS). In renovascular hypertension, this presents as a reactive perivascular and …