Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …

The biosynthesis of endogenous brain-derived neurotrophic factor (BDNF) has thus far been
examined in neurons where it is expressed at very low levels, in an activity-dependent …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

In Huntington's disease (HD), mutant Huntingtin (mHtt) protein causes striatal neuron
dysfunction, synaptic loss, and eventual neurodegeneration. To understand the mechanisms …

Impaired wound healing in the diabetic foot is a major problem often leading to amputation.
Mast cells have been shown to regulate wound healing in diabetes. We developed an …

Background Endothelial progenitor cells (EPCs) may be recruited from bone marrow to
sustain tumor vascularisation and promote the metastatic switch. Understanding the …

Abstract Store-operated Ca 2+ entry (SOCE) is critical for Ca 2+ signaling in nonexcitable
cells; however, its role in the regulation of cardiomyocyte Ca 2+ homeostasis has only …

Ca2+ channels regulate many crucial processes within cells and their abnormal activity can
be damaging to cell survival, suggesting that they might represent attractive therapeutic …