The epithelial-to-mesenchymal transition (EMT) in the development and metastasis of malignant pleural mesothelioma

V Ramundo, G Zanirato, E Aldieri - International Journal of Molecular …, 2021 - mdpi.com
Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with
asbestos exposure and is characterized by a very difficult pharmacological approach. One of …

The emerging roles of histone demethylases in cancers

D Tong, Y Tang, P Zhong - Cancer and Metastasis Reviews, 2024 - Springer
Modulation of histone methylation status is regarded as an important mechanism of
epigenetic regulation and has substantial clinical potential for the therapy of diseases …

A panel of emerging EMT genes identified in malignant mesothelioma

L Wu, S Amjad, H Yun, S Mani, M de Perrot - Scientific reports, 2022 - nature.com
Malignant mesothelioma (MESO) is a highly aggressive cancer with poor prognosis.
Epithelial–mesenchymal transition (EMT) is a critical process in malignancies involved in …

Prognostic value of EMT gene signature in malignant mesothelioma

L Wu, K Yoshihara, H Yun, S Karim, N Shokri… - International Journal of …, 2023 - mdpi.com
Malignant mesothelioma (MESO) consists of epithelioid, biphasic, and sarcomatoid
subtypes with different epithelial–mesenchymal transition (EMT) phenotypes. We previously …

Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement

JB Assié, D Jean - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Pleural mesothelioma is a rare and aggressive cancer originating in the pleura,
with a devastating prognosis and limited treatment options. There have been significant …

YB‐1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2

K Schelch, S Eder, B Zitta, M Phimmachanh… - Molecular …, 2024 - Wiley Online Library
Pleural mesothelioma (PM) is characterized by rapid growth, local invasion, and limited
therapeutic options. The multifunctional oncoprotein Y‐box‐binding protein‐1 (YB‐1) is …

[HTML][HTML] Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

H Sun, Y Gao, X Ma, Y Deng, L Bi, L Li - Genes & Diseases, 2024 - Elsevier
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction
acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation …

[HTML][HTML] 恶性胸膜间皮瘤靶向治疗的研究进展

FU Fen, Z Yang, S Hong - Chinese Journal of Lung Cancer, 2024 - ncbi.nlm.nih.gov
恶性胸膜间皮瘤( malignant pleural mesothelioma, MPM) 是侵袭性极强的罕见胸膜表面恶性
肿瘤, 危险因素包括吸入石棉、 遗传因素、 基因突变等。 现有的化疗、 抗血管生成治疗 …

[PDF][PDF] 恶性胸膜间皮瘤靶向治疗的研究进展

傅芬, 张扬, 沈红 - pdfs.semanticscholar.org
恶性胸膜间皮瘤(malignant pleural mesothelioma, MPM) 是侵袭性极强的罕见胸膜表面恶性
肿瘤, 危险因素包括吸入石棉, 遗传因素, 基因突变等. 现有的化疗, 抗血管生成治疗 …

Microbiomes, epigenomics, immune response, and splicing signatures interplay: Potential use of combination of regulatory pathways as targets for malignant …

BP Setlai, ZL Mkhize-Kwitshana, R Mehrotra… - International Journal of …, 2022 - mdpi.com
Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high
mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries …