1, 3, 4-thiadiazole: A privileged scaffold for drug design and development
X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - ingentaconnect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: A review
M Bian, Q Ma, Y Wu, H Du… - Journal of enzyme …, 2021 - Taylor & Francis
Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …
and diseases can promote inflammatory response, and two possibly induces each other in a …
An overview on 1, 2, 4-triazole and 1, 3, 4-thiadiazole derivatives as potential anesthesic and anti-inflammatory agents
The aim. The purpose of this review is to summarize data on the synthesis and structural
modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as …
modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as …
Novel quinolone substituted 1, 3, 4-oxadiazole derivatives: design, synthesis, antimicrobial and anti-inflammatory potential
A novel series of quinolone-substituted 1, 3, 4-oxadiazole derivatives 4 (a–l) have been
designed and synthesized. The target compounds were investigated for their antibacterial …
designed and synthesized. The target compounds were investigated for their antibacterial …
Mitogen activated protein kinase-1 and cell division control protein-42 are putative targets for the binding of novel natural lead molecules: a therapeutic intervention …
D Gopal, AG Muddebihalkar… - Journal of …, 2020 - Taylor & Francis
Candida albicans, fungal yeast causes several lethal infections in immune-suppressed
patients and recently emerged as drug-resistant pathogens worldwide. The present study …
patients and recently emerged as drug-resistant pathogens worldwide. The present study …
An effort to find new α-amylase inhibitors as potent antidiabetics compounds based on indole-based-thiadiazole analogs
Inhibition of α-amylase enzyme is of key significance for the therapy of diabetes mellitus
(DM). Numerous indole-based compounds have earlier been described for broad range of …
(DM). Numerous indole-based compounds have earlier been described for broad range of …
Design, Synthesis, and Pharmacological Evaluation of Substituted Oxadiazole-Pyridazin-3-One Derivatives as Antioxidant and Antimicrobial Agents
M Saini, R Das, DK Mehta - Anti-Infective Agents, 2022 - ingentaconnect.com
Background: The chemical modification of pyridazinone leads to a potent therapeutic agent.
Aims: A series of novel analogues of 4, 5-dichloro-6-(substituted-benzyl)-2-(5-mercapto-[1 …
Aims: A series of novel analogues of 4, 5-dichloro-6-(substituted-benzyl)-2-(5-mercapto-[1 …
Synthesis, Characterization, and Evaluation of the Antibacterial Activity of Novel 5-aryl-2-amino 1, 3, 4 Thiadiazole Derivatives
RS Baiwn, HN Alsaad, AK Mohammed - 2022 - journals.ekb.eg
The antibiotic resistant crisis is a worldwide phenomenon that threatens the global health.
The misuse and overuse of antibiotics as well as the inadequate development of new …
The misuse and overuse of antibiotics as well as the inadequate development of new …
Study anticancer and antioxidant activity of the prepared compound 2-methoxy-4-{(E)-[2-(5-sulfanyl-1, 3, 4-thiadiazol-2yl) hydrazinylidene] methyl} phenol.
S Nasir, I Flifel - Onkologia i Radioterapia, 2023 - search.ebscohost.com
The current study paid attention to the preparation of a chemical compound, 2-methoxy-4-
{(E)-[2-(5-sulfanyl-1, 3, 4-thiadiazol 2yl) hydrazinyli dene] methyl} phenol and its complexes …
{(E)-[2-(5-sulfanyl-1, 3, 4-thiadiazol 2yl) hydrazinyli dene] methyl} phenol and its complexes …
Synthesis, Characterization, And Evaluation Of The Antibacterial Activity Of Novel 5-aryl-2-amino 1, 3, 4 Thiadiazole Derivatives
R Salman, H Alsaad, A Khamas - Egyptian Journal of …, 2022 - ejchem.journals.ekb.eg
The antibiotic resistant crisis is a worldwide phenomenon that threatens the global health.
The misuse and overuse of antibiotics as well as the inadequate development of new …
The misuse and overuse of antibiotics as well as the inadequate development of new …