Owing to the unique ability of antibodies that bind the membrane proximal region of the
extracellular domain to trigger conformational changes leading to affinity modulation and …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Metabolic adjustments are necessary for the initiation, proliferation, and spread of cancer
cells. Although mitochondria have been shown to move to cancer cells from their …

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …

CD38 (also known as T10) was identified in the late 1970s in the course of pioneering work
carried out at the Dana‐Farber Cancer Center (Boston, MA) that focused on the identification …

Platelets are specialized blood cells that play central roles in physiologic and pathologic
processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense …

Endothelial cells situated at the interface between blood and the vessel wall play a crucial
role in controlling vascular tone and homeostasis, particularly in determining the expression …

Cellular interactions with the extracellular matrix and with neighboring cells profoundly
influence a variety of signaling events including those involved in mitogenesis, survival, and …

Inflammation is a basic pathological mechanism that underlies many diseases. An important
component of the inflammatory response is the passage of plasma components and …

Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient
mice have revealed that this molecule plays an important role in controlling the activation …