The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Endothelial dysfunction is characterized by a shift of the actions of the endothelium toward
reduced vasodilation, a proinflammatory state, and prothrombic properties. It is associated …

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes …

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic
complications. However, intervention studies with classic antioxidants, such as vitamin E …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …