The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a
highly promising target for next-generation antibacterials. This system includes two terminal …

Antibiotics can stimulate or depress gene expression in bacteria. The analysis of
transcriptional responses of Mycobacterium to antimycobacterial compounds has improved …

The capacity of Mycobacterium tuberculosis (Mtb) to tolerate multiple antibiotics represents a
major problem in tuberculosis (TB) management. Heterogeneity in Mtb populations is one of …

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …

Host immune response to COVID-19 plays a significant role in regulating disease severity.
Although big data analysis has provided significant insights into the host biology of COVID …

Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most
prokaryotes. M. tuberculosis (Mtb) encodes a complete SUF system, the depletion of which …

Cytochrome bd (Cyt-bd) oxidase, one of the two terminal oxidases in the Mycobacterium
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …

The Mycobacterium tuberculosis genome harbors nine toxin-antitoxin (TA) systems that are
members of the mazEF family, unlike other prokaryotes, which have only one or two …

Iron-sulfur (Fe-S) cluster proteins carry out essential cellular functions in diverse organisms,
including the human pathogen Mycobacterium tuberculosis (Mtb). The mechanisms …

The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M …