Molecular mechanisms linking oxidative stress and diabetes mellitus

H Yaribeygi, T Sathyapalan, SL Atkin… - … medicine and cellular …, 2020 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction

KN Keane, VF Cruzat, R Carlessi… - Oxidative medicine …, 2015 - Wiley Online Library
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …

Nutrient regulation of insulin secretion and action

P Newsholme, V Cruzat, F Arfuso… - Journal of …, 2014 - joe.bioscientifica.com
Pancreatic β-cell function is of critical importance in the regulation of fuel homoeostasis, and
metabolic dysregulation is a hallmark of diabetes mellitus (DM). The β-cell is an intricately …

Role of nitric oxide in insulin secretion and glucose metabolism

Z Bahadoran, P Mirmiran, A Ghasemi - Trends in Endocrinology & …, 2020 - cell.com
Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability
is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve …

Amino acid supplementation and impact on immune function in the context of exercise

VF Cruzat, M Krause, P Newsholme - … of the international Society of Sports …, 2014 - Springer
Moderate and chronic bouts of exercise may lead to positive metabolic, molecular, and
morphological adaptations, improving health. Although exercise training stimulates the …

[HTML][HTML] Nitric oxide levels in patients with diabetes mellitus: A systematic review and meta-analysis

TS Assmann, LA Brondani, AP Boucas, J Rheinheimer… - Nitric Oxide, 2016 - Elsevier
Background Altered serum nitric oxide (NO) levels in patients with diabetes mellitus (DM)
have been reported by different studies; however, results are still controversial. Until this …

The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric …

M Krause, J Rodrigues-Krause, C O'Hagan… - European journal of …, 2014 - Springer
Aims To investigate the effect of 16 weeks of aerobic training performed at two different
intensities on nitric oxide (tNO x) availability and iNOS/nNOS expression, oxidative stress …

Heat shock proteins and heat therapy for type 2 diabetes: pros and cons

M Krause, MS Ludwig, TG Heck… - Current Opinion in …, 2015 - journals.lww.com
Heat therapy is a promising and inexpensive tool for the treatment of obesity and diabetes.
We proposed that transient increments in nitric oxide and heat shock protein 70 levels may …

Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and …

J Rodrigues-Krause, M Krause, IMG Rocha… - Nutrients, 2018 - mdpi.com
l-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic
diseases. However, the use of distinct l-arginine sources, intervened populations, and …

Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?

M Krause, F Gerchman, R Friedman - Diabetology & Metabolic Syndrome, 2020 - Springer
Chronic inflammation is involved in the pathogenesis of several metabolic diseases, such as
obesity and type 2 diabetes mellitus (T2DM). With the recent worldwide outbreak of …