Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular …

B-cell activation plays a crucial part in the immune system and is initiated via interaction
between the B cell receptor (BCR) and specific antigens. In recent years with the help of …

Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic
microenvironment but the cellular processes driving this are incompletely understood. Here …

T cell receptor (TCR) engagement opens Ca2+ release-activated Ca2+ (CRAC) channels
and triggers formation of an immune synapse between T cells and antigen-presenting cells …

Galectins are glycan-binding proteins that regulate innate and adaptive immune responses,
and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 …

Calcium influx through store-operated Ca2+ release-activated Ca2+ channels (CRAC
channels) is a well-defined mechanism of generating cellular Ca2+ elevations that regulates …

Tunneling nanotubes (TNTs) are long intercellular connecting structures providing a special
transport route between two neighboring cells. To date TNTs have been reported in different …

Simple Summary Tunneling nanotubes (TNTs) are cytoplasmic channels which regulate the
contacts between cells and allow the transfer of several elements, including ions …

Calcium is a universal second messenger present in all eukaryotic cells. The mobilization
and storage of Ca2+ ions drives a number of signaling-related processes, stress–responses …

Mechano-transduction is an emerging but still poorly understood component of T cell
activation. Here we investigated the ligand-dependent contribution made by contractile …