Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …

Multiple myeloma (MM) is a malignancy that is often driven by MYC and that is sustained by
IRF4, which are upregulated by super-enhancers. IKZF1 and IKZF3 bind to super-enhancers …

Over the last two decades, there have been extensive efforts to develop small-molecule
inhibitors of protein–protein interactions (PPIs) as novel therapeutics for cancer, including …

An in silico target discovery pipeline was developed by including a directional and weighted
molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH) …

Chemical discovery efforts commonly target individual protein domains. Many proteins,
including the EP300/CBP histone acetyltransferases (HATs), contain several targetable …

Castration resistant prostate cancer (CRPC) remains an incurable disease stage with
ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300 …

Multiple myeloma (MM) is an incurable plasma cell malignancy that exploits transcriptional
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …

Post-translational modifications (PTMs) play a crucial role in regulating protein function, and
their dysregulation is frequently associated with various diseases. The emergence of …

Lysine acetylation is a major post-translational modification in histones and other proteins
that is catalysed by the 'writer'lysine acetyltransferases (KATs) and mediates interactions …