Chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …
Dissecting the role of the CXCL12/CXCR4 axis in acute myeloid leukaemia
EE Ladikou, T Chevassut, CJ Pepper… - British journal of …, 2020 - Wiley Online Library
Acute myeloid leukaemia (AML) is the most common adult acute leukaemia with the lowest
survival rate. It is characterised by a build‐up of immature myeloid cells anchored in the …
survival rate. It is characterised by a build‐up of immature myeloid cells anchored in the …
Treatment with Ibrutinib Inhibits BTK- and VLA-4–Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo
SEM Herman, RZ Mustafa, J Jones, DH Wong… - Clinical Cancer …, 2015 - AACR
Purpose: Ibrutinib leads to a transient lymphocytosis in patients with chronic lymphocytic
leukemia (CLL) that develops within hours of starting drug and is due to the efflux of cells …
leukemia (CLL) that develops within hours of starting drug and is due to the efflux of cells …
Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells
The vast majority of cases of follicular lymphoma (FL), but not normal B cells, acquire N-
glycosylation sites in the immunoglobulin variable regions during somatic hypermutation …
glycosylation sites in the immunoglobulin variable regions during somatic hypermutation …
Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib
A Guo, P Lu, N Galanina, C Nabhan, SM Smith… - …, 2015 - pmc.ncbi.nlm.nih.gov
In chronic lymphocytic leukemia (CLL), patients with unmutated immunoglobulin heavy
chain variable region gene (UM-CLL) have worse outcomes than mutated CLL (M-CLL) …
chain variable region gene (UM-CLL) have worse outcomes than mutated CLL (M-CLL) …
Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration
M Pasikowska, E Walsby, B Apollonio… - Blood, The Journal …, 2016 - ashpublications.org
Several lines of evidence suggest that homing of tumor cells to lymphoid tissue contributes
to disease progression in chronic lymphocytic leukemia (CLL). Here, we demonstrate that …
to disease progression in chronic lymphocytic leukemia (CLL). Here, we demonstrate that …
CD 49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemia
P Strati, SA Parikh, KG Chaffee… - British journal of …, 2017 - Wiley Online Library
CD 49d is a surface integrin that is expressed on chronic lymphocytic leukaemia (CLL) cells,
and strongly correlates with more aggressive disease. Given its association with cell‐cell …
and strongly correlates with more aggressive disease. Given its association with cell‐cell …
[HTML][HTML] Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors
The mutational status of immunoglobulin heavy-chain variable-region (IGVH) genes is
considered the most powerful marker of clinical outcome in CLL. 5, 6 However, patients with …
considered the most powerful marker of clinical outcome in CLL. 5, 6 However, patients with …
Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia
NA Heerema, N Muthusamy, Q Zhao… - …, 2020 - pmc.ncbi.nlm.nih.gov
Mutations of the IGH variable region in patients with chronic lymphocytic leukemia are
associated with a favorable prognosis, whereas cytogenetic complexity (≥ 3 unrelated …
associated with a favorable prognosis, whereas cytogenetic complexity (≥ 3 unrelated …
The outcome of Chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98 …
Z Davis, F Forconi, A Parker, A Gardiner… - British journal of …, 2016 - Wiley Online Library
IGHV gene mutational status has prognostic significance in chronic lymphocytic leukaemia
(CLL) but the percentage of mutations that correlates best with clinical outcome remains …
(CLL) but the percentage of mutations that correlates best with clinical outcome remains …