The haemoflagellate protozoan Trypanosoma cruzi (T. cruzi) is the causative agent of
Chagas disease (CD), a potentially life-threatening disease. Little by little, remarkable …

Parasitic diseases are still a huge problem for mankind. They are becoming the main cause
of chronic diseases in the world. Migration of the population, pollution of the natural …

We have synthesized the pyrazole-bearing Schiff base derivatives (5a–5e) and (6a–6h) then
the structural confirmation was supported by various spectral analyses. The antibacterial …

The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …

Chagas disease is a disease that is emerging in North America and Europe countries.
Benznidazole is the main drug available, but it has high toxicity and low efficacy in the …

Chagas disease, a chronic and silent disease caused by Trypanosoma cruzi, is currently a
global public health problem. The treatment of this neglected disease relies on …

This study presents a comprehensive exploration of the synthesis of novel compounds
targeting Chagas Disease (CD) caused by Trypanosoma cruzi. It is a global health threat …

A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole
isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1, 3, 4-thiadiazole hybrids …

Chagas disease, a century-old disease that mainly affects the impoverished population in
Latin America, causes high morbidity and mortality in endemic countries. The available …

Chagas disease, a silent but widespread disease that mainly affects a socioeconomically
vulnerable population, lacks innovative safe drug therapy. The available drugs …