The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …

At the onset of division, the cell forms a spindle, a precise self-constructed micromachine
composed of microtubules and the associated proteins, which divides the chromosomes …

Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …

When a cell starts to divide, it forms a spindle, a micro-machine made of microtubules, which
separates the duplicated chromosomes. The attachment of microtubules to chromosomes is …

Accurate chromosome segregation requires sister kinetochores to biorient, attaching to
opposite spindle poles. To this end, the mammalian kinetochore destabilizes incorrect …

Active forces generated at kinetochores move chromosomes, and the dynamic spindle must
robustly anchor kinetochore fibers (k-fibers) to bear this load. The mammalian spindle bears …

The spindle segregates chromosomes at cell division, and its task is a mechanical one.
While we have a nearly complete list of spindle components, how their molecular-scale …

Accurate chromosome segregation in mitosis depends on proper connections of sister
chromatids, through microtubules, to the opposite poles of the early mitotic spindle …

During mitosis, tension develops across the centromere as a result of spindle-based forces.
Metaphase tension may be critical in preventing mitotic chromosome segregation errors …

During mitosis, kinetochore-attached microtubules form bundles (k-fibers) in which many
filaments grow and shorten in near-perfect unison to align and segregate each …