The blood–brain barrier (BBB) limits the access of substances to the central nervous system
(CNS) which hinders the treatment of pathologies affecting the brain and the spinal cord …

Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response
that results in generalized organ dysfunction. The exacerbated peripheral inflammation can …

Objective The aim of this systematic review and meta‐analysis (SR‐MA) was to identify
signaling molecule profiles and blood‐derived biomarkers in migraine and cluster headache …

Background Intranasal agents may be ideal for the treatment of migraine patients. Many new
acute intranasal-specific therapies have been developed, but few of them have been directly …

Objectives This study aimed to establish a pharmacodynamic model to quantitatively
compare the efficacy characteristics of seven kinds of triptans and their different dosage …

Background In a previous randomized, double-blind, proof-of-concept study in rapidly
escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated …

Introduction Drugs need to enter the systemic circulation efficiently before they can cross the
blood–brain barrier and reach the central nervous system. Although the respiratory tract is …

The advent of the triptans revolutionized acute migraine treatment. The older migraine-
specific drugs, the ergot alkaloids (ergotamine and dihydroergotamine), also relieve …

Background We aim to describe and compare patients and general practitioners' opinions
about the different variables related to acute and preventive treatment for migraine. Patients …

Global prevalence of neurological disorders such as Parkinson's disease, Alzheimer's
disease, epilepsy, and multiple sclerosis is steadily increasing, but, there is still no effective …