Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

Inter-individual genomic variations have recently become evident with advances in
sequencing techniques and genome-wide array comparative genomic hybridization. Among …

В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …

The science of genetics is undergoing a paradigm shift. Recent discoveries, including the
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …

Background Polybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that
accumulate in human tissues and are potential toxicants. Concentrations of PBDEs in …

Structural genetic variation, including copy-number variation (CNV), constitutes a substantial
fraction of total genetic variability and the importance of structural genetic variants in …

Glutathione transferases (GST) catalyze the conjugation of glutathione (GSH) with
electrophiles, many of which may otherwise interact with protein or DNA. In select cases …

Background: Because asthma has been associated with exercise and ozone exposure, an
association likely mediated by oxidative stress, we hypothesised that glutathione-S …

Fanciulli M, Petretto E, Aitman TJ. Gene copy number variation and common human
disease. Variation in gene copy number is increasingly recognized as a common, heritable …

Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as
lung allergens and irritants. Exposure to these substances can lead to inflammatory …