Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Sepsis is aggravated by an inappropriate immune response to invading microorganisms,
which occasionally leads to multiple organ failure. Several lines of evidence suggest that the …

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an
increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

With current plans for manned missions to Mars and beyond, the need to better understand,
prevent, and counteract the harmful effects of long-duration spaceflight on the body is …

Rationale: In heart failure (HF), impaired sarcoplasmic reticulum (SR) Ca2+ release and
cytosolic Na+ overload depress mitochondrial Ca2+ (mCa2+) signaling, resulting in a …

Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the
cellular and molecular signature of this disease is largely unclear. Using single-nucleus …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex, and are dependent …

Cardiovascular diseases are the leading cause of death in most developed nations. While it
has received the least public attention, aging is the dominant risk factor for developing …