Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked d-
glucosamine and N-acetyl-d-glucosamine. It is one of the major cationic polymers and the …

The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic
acids in gene therapy. Factors influencing the transfection efficiency of chitosan-based …

RNA interference (RNAi), a gene regulatory process mediated by small interfering RNAs
(siRNAs), has made remarkable progress as a potential therapeutic agent against various …

Background Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, has been
shown to play a role in the pathophysiology of rheumatoid arthritis. Silencing TNFα …

In this paper, we compared the transfection efficiency and cytotoxicity of methylglycol-
chitosan (MG-CS) and diethylaminoethyl-chitosan (DEAE-CSI and DEAE-CSII with degrees …

Advanced biomaterials provide an interesting and versatile platform to implement new and
more effective strategies to fight bacterial infections. Chitosan is one of these biopolymers …

Polysaccharide-based polyelectrolyte complexes (PECs) are of great interest for the
development of drug delivery systems, as they are easily prepared and exhibit a wide range …

Purpose Diethylaminoethyl-chitosan (DEAE-CH) is a derivative with excellent potential as a
delivery vector for gene therapy applications. The aim of this study is to evaluate its …

We report on a new approach to increase the removal of cesium from contaminated clays
based on the intercalation of a cationic polyelectrolyte into the clay interlayers. A highly …

Pullulan is a natural polysaccharide of potential interest for biomedical applications due to
its non-toxic, non-immunogenic and biodegradable properties. The aim of this work was to …