Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Low and oscillatory wall shear stress is widely assumed to play a key role in the initiation
and development of atherosclerosis. Indeed, some studies have relied on the low shear …

Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture
and erosion. Methods and results Intracoronary optical coherence tomography performed in …

Coronary plaque rupture is the most common cause of vessel thrombosis and acute
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …

We present a survey of recent advancements in the emerging field of patient-specific
modeling (PSM). Researchers in this field are currently simulating a wide variety of tissue …

Coronary artery atherosclerosis is a local, multifactorial, complex disease, and the leading
cause of death in the US. Complex interactions between biochemical transport and …

Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis
of CAD's physiological significance is of utmost importance for guiding individualized risk …

OBJECTIVE: While the correlation of atherosclerotic plaque locations with local wall shear
stress magnitude has been evaluated previously by other investigators in both right (RCA) …

Mathematical models have long been used for prediction of dynamics in biological systems.
Recently, several efforts have been made to render these models patient specific. One way …