Differential regulation of type I and type III interferon signaling

ML Stanifer, K Pervolaraki, S Boulant - International journal of molecular …, 2019 - mdpi.com
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

Role of host-mediated post-translational modifications (PTMs) in RNA virus pathogenesis

R Kumar, D Mehta, N Mishra, D Nayak… - International Journal of …, 2020 - mdpi.com
Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir

HS Lo, KPY Hui, HM Lai, X He, KS Khan… - ACS central …, 2021 - ACS Publications
The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global threat to human health. Using …

Gender specific differences in disease susceptibility: the role of epigenetics

L Migliore, V Nicoli, A Stoccoro - Biomedicines, 2021 - mdpi.com
Many complex traits or diseases, such as infectious and autoimmune diseases, cancer,
xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the …

Redox control in the pathophysiology of influenza virus infection

KK Chen, M Minakuchi, K Wuputra, CC Ku, JB Pan… - BMC microbiology, 2020 - Springer
Triggered in response to external and internal ligands in cells and animals, redox
homeostasis is transmitted via signal molecules involved in defense redox mechanisms …

Mechanisms of selected functional foods against viral infections with a view on COVID-19: Mini review

A Haslberger, U Jacob, B Hippe, H Karlic - Functional Foods in Health and …, 2020 - ffhdj.com
Following research obtained from the previous SARS and MERS outbreaks, we've gained
knowledge about the mechanisms of bioactive plant ingredients against the attachment and …

The battle for autophagy between host and influenza A virus

A Zhou, W Zhang, X Dong, M Liu, H Chen, B Tang - Virulence, 2022 - Taylor & Francis
Influenza A virus (IAV) is an infectious pathogen, threatening the population and public
safety with its epidemics. Therefore, it is essential to better understand influenza virus …

Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection

M Salgado-Albarrán, EI Navarro-Delgado… - NPJ systems biology …, 2021 - nature.com
COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome
coronavirus 2), which has caused a global outbreak. Current research efforts are focused on …

DOT1L maintains NK cell phenotype and function for optimal tumor control

H Sudholz, IS Schuster, M Foroutan, X Sng… - Cell Reports, 2024 - cell.com
Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role
in natural killer (NK) cell biology within the tumor microenvironment (TME) remains largely …

The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival

PR Singh, V Dadireddy, S Udupa, SM Kalladi… - Nature …, 2023 - nature.com
Mycobacterium tuberculosis has evolved several mechanisms to counter host defense
arsenals for its proliferation. Here we report that M. tuberculosis employs a multi-pronged …