Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Catalytic reductive coupling of enone, acrylate, or vinyl heteroaromatic pronucleophiles with
carbonyl or imine partners offers an alternative to base-mediated enolization in aldol-and …

Atom-efficient processes that occur via addition, redistribution, or removal of hydrogen
underlie many large-volume industrial processes and pervade all segments of chemical …

Hydrogenation of 1, 3-enynes 1a− e in the presence of heterocyclic aromatic aldehydes and
ketones using chirally modified cationic rhodium precatalysts results in reductive coupling to …

Aldol reactions have been and are widely applied for the preparation of β-hydroxy
aldehydes, β-hydroxy ketones or α, β-unsaturated aldehydes or ketones through addition or …

Although catalytic hydrogenation has been practiced for over a century, use of hydrogen as
a terminal reductant in catalytic C− C bond formation has been restricted to processes …

Catalytic hydrogenation of 1, 3-enynes 1a− 7a in the presence of ethyl pyruvate and related
activated ketones using chirally modified cationic rhodium catalysts results in reductive …

Rhodium-catalyzed hydrogenation of 1, 3-enynes 1a− 8a and 1, 3-diynes 9a− 13a at
ambient temperature and pressure in the presence of ethyl (N-tert-butanesulfinyl) …

We report the first enantioselective reductive aldol couplings of vinyl ketones, which were
achieved through the design of a novel monodentate TADDOL-like phosphonite ligand …

Catalytic enantioselective hydrogen autotransfer reactions for the direct conversion of lower
alcohols to higher alcohols are catalogued and their application to the total synthesis of …