Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a
fundamental role in metazoan development. Signals exchanged between neighboring cells …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

We describe a genetic mosaic system in Drosophila, in which a dominant repressor of a cell
marker is placed in trans to a mutant gene of interest. Mitotic recombination events between …

The road to carbon nanotube transistors | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

We have studied the role of Notch-1 and its antagonist Numb in the activation of satellite
cells during postnatal myogenesis. Activation of Notch-1 promoted the proliferation of …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Ciliogenesis precedes lineage-determining signaling in skin development. To understand
why, we performed shRNA-mediated knockdown of seven intraflagellar transport proteins …

▪ Abstract The Notch signaling pathway has long been known to influence cell fate in the
developing nervous system. However, this pathway has generally been thought to inhibit the …

Cellular decisions of self-renewal or differentiation arise from integration and reciprocal
titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect …