COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …

Idiopathic pulmonary fibrosis is a progressive and usually fatal lung disease characterized
by fibroblast proliferation and extracellular matrix remodeling, which result in irreversible …

The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-
9) represents the largest and most complex member. We focus here on the biochemical …

Oxidative stress has been implicated in the pathophysiology of myocardial failure. We tested
the hypothesis that oxidative stress can regulate extracellular matrix in cardiac fibroblasts …

Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4. 24.35)
is an MMP that is present in low quantities in the healthy adult lung, but much more …

Fibroblast proliferation and extracellular matrix accumulation characterize idiopathic
pulmonary fibrosis (IPF). We evaluated the presence of tissue inhibitor of metalloproteinase …

Background A central feature in the pathogenesis of COPD is the inflammation coexisting
with an abnormal protease/antiprotease balance. However, the possible role of different …

Dysregulation of the myocardial extracellular matrix contributes to abnormal cardiac muscle
function. Changes in the balance between matrix deposition and matrix degradation by …

Peyronie's disease (PD) is characterized with formation of fibrous plaques which result in
penile deformity, pain, and erectile dysfunction. The aim of this study was to investigate the …

Pulmonary fibrosis has an aggressive course and is usually fatal an average of 3 to 6 years
after the onset of symptoms. Pulmonary fibrosis is associated with deposition of extracellular …