Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into …

O Lockridge, LM Schopfer - Chemico-biological interactions, 2023 - Elsevier
The acute effects of exposure to organophosphorus toxicants are explained by inhibition of
acetylcholinesterase activity. However, the mechanisms that explain long term illness …

Cellular Fluorescence Imaging Technology for Food Risk and Function Evaluation

Z Ning, Y Zhang, S Zhang, X Lin, L Kang… - Trends in Food Science …, 2024 - Elsevier
Cellular fluorescence imaging (CFI) uses fluorescent substances to label specific
biomarkers in cells, recording their dynamic changes via fluorescent signals to study …

Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling [S]

JA Wepy, JJ Galligan, PJ Kingsley, S Xu… - Journal of lipid …, 2019 - ASBMB
Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling
processes and the regulation of cell membrane structure. LysoPLs are metabolized through …

Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3, 5, 6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators

G Echeverri-Jaramillo, B Jaramillo-Colorado… - Ecotoxicology, 2021 - Springer
Chlorpyrifos (CP) is one of the organophosphate insecticides most used worldwide today.
Although the main target organ for CP is the nervous system triggering predominantly …

Ecotoxicological assessment of perchlorate using in vitro and in vivo assays

R Acevedo-Barrios, C Sabater-Marco… - … Science and Pollution …, 2018 - Springer
Perchlorate is an inorganic ion widespread in the environment, generated as a natural and
anthropogenic pollutant, with known endocrine disruption properties in the thyroid gland …

Rabbit antidiethoxyphosphotyrosine antibody, made by single B cell cloning, detects chlorpyrifos oxon-modified proteins in cultured cells and immunopurifies modified …

S Onder, M Van Grol, A Fidder, G Xiao… - Journal of proteome …, 2021 - ACS Publications
Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of
neurodegenerative disease. The mechanism of neurotoxicity is independent of …

Neurite outgrowth inhibitory levels of organophosphates induce tissue transglutaminase activity in differentiating N2a cells: evidence for covalent adduct formation

IS Almami, MA Aldubayan, SG Felemban… - Archives of …, 2020 - Springer
Organophosphate compounds (OPs) induce both acute and delayed neurotoxic effects, the
latter of which is believed to involve their interaction with proteins other than …

The cytoskeleton as a non-cholinergic target of organophosphate compounds

D Hernandez-Toledano, L Vega - Chemico-Biological Interactions, 2021 - Elsevier
Current organophosphate (OP) toxicity research now considers potential non-cholinergic
mechanisms for these compounds, since the inhibition of acetylcholinesterase (AChE) …

Behavioral abnormalities and phosphorylation deficits of extracellular signal-regulated kinases 1 and 2 in rat offspring of the maternal immune activation model

W Li, F Sun, X Guo, Y Hu, S Ding, M Ding, M Song… - Physiology & …, 2020 - Elsevier
Extracellular signal-regulated kinase (ERK) signal transduction is known to be associated
with neurogenesis and neuronal differentiation and as such may be related to the synaptic …

Mining the effect of the neonicotinoids imidacloprid and clothianidin on the chemical homeostasis and energy equilibrium of primary mouse neural stem/progenitor …

E Fotopoulou, M Lykogianni, E Papadimitriou… - Pesticide Biochemistry …, 2020 - Elsevier
The projection of plant protection products'(PPPs) toxicity to non-target organisms at early
stages of their development is challenging and demanding. Recent developments in …